Occurrence of Clostridium difficile infections due to PCR ribotype 027 in Bucharest, Romania

Occurrence of Clostridium difficile infections due to PCR ribotype 027 in Bucharest, Romania

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Introduction: Little is known about prevailing ribotypes of Clostridium difficile infection in Romania where CDI is not a mandatory notifiable disease.Methodology: We studied 64 non-duplicate C.difficile isolates from patients hospitalised at the National Institute of Infectious Diseases, Bucharest, Romania between March 2011 and March 2012.Results: il barone wine Sixty-three of the 64 C.difficile isolates produced toxins A and B whereas 44 (69%) isolates produced a binary toxin.

Ribotype 027 accounted for 43 (68%) of the 63 toxigenic strains.The remaining 20 isolates belonged to ribotypes 018 (n = 9), 012 (n = 3), and, with one isolate each, 014, 031, 081, 416, 433, 500, 507 and PR03035 (new ribotype).Information on hospital mortality was available for 62 of the 64 patients; among these 62 cases, 4 (6.4%) ended fatal.Recurrence was documented for 11 (18.

3%) of the 60 patients for whom this information was available.Multilocus variable-number tandem repeat analysis of the 43 isolates of ribotype 027 yielded a unique cluster for the Romanian isolates when compared to Austrian or Italian isolates.Conclusion: Our findings sustain the hypothesis of a recent emerged outbreak of quadruple topical ointment for dogs C.difficile PCR ribotype 027 infections in the area of Bucharest.